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Myostatin ELISA/EIA Kit
For the determination of Myostatin in human serum and plasma
 
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 INTENDED USE
This enzyme immunoassay is intended for the quantitative determination of myostatin in human serum and plasma. For in vitro diagnostic use only.
 
 SUMMARY
 

Myostatin belongs to the transforming growth differentiation factor-ß (TGF-ß) super family. The molecule is a negative regulator of muscle growth, but details about the actions of myostatin are uncertain (Roth and Walsh, 2004). 

   
 

Myostatin was first identified in 1997 by McPherron et al. They found out that null-mutant knockout mice were significantly larger than wild-type animals and exhibited a large and widespread increase in skeletal muscle mass due to an increase of muscle fiber number (hyperplasia) and thickness (hypertrophy). Other groups identified mutations in the myostatin gene in naturally bred “double-muscles” cattle breeds. 

   

Similar to the findings in animal models, increased myostatin immuno-reactivity or expression has been observed in HIV-infected men with muscle wasting (Gonzales-Cadavid et al. 1998), after prolonged bed rest in young men (Zachwieja et al. 1999) and in older men and women with muscle wasting (Yarasheski KE et al. 2002).

 
 

Shi et al. (2007) and others have found that myostatin deficiency inhibits adipogenesis in vivo, even when mice are fed a high-fat diet. Transgenic overexpression of myostatin pro-peptide, which inhibits myostatin signaling, also inhibits body fat gain with a high-fat diet (Zhao et al. 2005). Similar alterations in myostatin signaling are associated with changes in body fat among humans.

   
 INDICATIONS  
Regulation of muscle growth
 
Muscle atrophy
 
Muscle wasting
 
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Myostatin EIA Protocol

 

 

 

Product Code IMM-K1012

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Other products: 

USC-E91653Hu   Human Myostatin ELISA

USC-E91653Mu   Mouse Myostatin ELISA

USC-E91653Ra    Rat Myostatin ELISA

USC-E91653Ga   Gallinaceous Myostatin ELISA

 

   
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