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ELISA anti-complement factor H

ELISA Kit for detection of IgG antibodies against human complement factor H in human serum or plasma.  

ELISA anti-complement factor H is intended for the quantitative detection of IgG antibodies against human complement factor H in human serum or plasma. Factor H is a complement regulatory glycoprotein that is found in human plasma in concentrations of 300 - 800 mg/L. Autoantibodies that inhibit factor H function cause complement dysregulation and they have been detected in about 10% of patients with atypical hemolytic uremic syndrome (aHUS). Atypical HUS is a clinical syndrom that is characterised by microangiopatic hemolytic anemia, thrombocytopenia and renal failure.
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Cat no. VID-ODZ-166.

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 Why using ELISA anti-complement factor H:
  • The first commercially available CE IVD certified ELISA
  • High sensitivity/specificity
  • Quantitative evaluation of the data

 

 

References:
• Anti-factor H autoantibody-associated hemolytic uremic syndrome: review of literature of the autoimmune form of HUS. Dragon-Durey MA, Blanc C, Garnier A, Hofer J, Sethi SK, Zimmerhackl LB. Semin Thromb Hemost. 2010 Sep;36(6):633-40.
• Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome. Dragon-Durey MA, Loirat C, Cloarec S, Macher MA, Blouin J, Nivet H, Weiss L, Fridman WH, Frémeaux-Bacchi V. J Am Soc Nephrol. 2005 Feb;16(2):555-63.
• Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. Józsi M, Licht C, Strobel S, Zipfel SL, Richter H, Heinen S, Zipfel PF, Skerka C.Blood. 2008 Feb 1;111(3):1512-4.

 
 
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