LiStarFish - Products fot medical research

Focus On
Oxidative Stress
PAT e d-ROMs Test (method of 2nd generation) + markers of cell damage (8OhdG, Ox-LDL, HEL, ...)


PAT Test

d-ROMs Test / d-ROMs Fast Test



Carbonylated Proteins







A delicate balance exists in our body between the production and the "swallowing" of free radicals and other reactive oxygen species (ROS).

Oxidative stress is a sort of "chimical stress" induced by the presence in our body of abnormal quantities of ROS and, in particular, of free radicals. This condition may be the consequence of an increased production of ROS and/or of a decreased efficiency of the antioxidant defence systems, usually appointed to theyr elimination.

The causes responsibles for the increase of free radicals may be located outside or inside the organism. Among the external causes there are some physical agents (e.g. UV and ionizing radiations), several chemical substances (e.g. hydrocarbons, herbicidals, contaminated food, drugs) and some infectious agents (e.g. virus and bacteria). Among the internal causes there are the exaggerate acceleration of cell metabolism (e.g. after strenuous exercise without proper training) and several diseases (e.g. obesity, diabetes, etc).

Li StarFish presents 2 innovative tests for the measurement of oxidative stress through a sample of capillary blood


PAT TEST: test for the measurement of the antioxidants at the systemic level (plasma). Simple, quick (1 minute) at low cost, ideal for the prevention and control of chronic systemic diseases and/or to monitor the effectiveness of outpatient treatment and/or therapeutic
d-ROMs test/d-ROMs Fast test: allows to determine the blood concentration of reactive oxygen metabolites (ROMs) and, particularly, that of hydroperoxides, which are markers and amplifiers of free radicals induced oxidative damage. In such a test the ROMs concentration is proportional to the intensity of the red coloration - photometrically evaluated - developed in a tampon system with acid pH, following the addition of the properly centrifugated blood sample and of a solution containing an aromatic alkilammine (chromogen). The test is evaluated in a conventional measuring unit called U CARR (from the chemist Carratelli, the inventor of the test). Normal values are from 250 to 300 U CARR; above 300 U CARR there is the oxidative stress, but for a thin borderline range (301-320 U CARR).
FRAS 4 Evolvo and FRAS5- Free Radical Analytical System - are new integrated analytical systems consisting of a dedicated photometer with an incorporated centrifuge, designed to allow the global assessment of oxidative stress, by means of two tests, i. e. d-ROMs test and PAT test, on a small sample of capillary blood, through finger-pick on a finger-tip.  fras4evolvo.jpg

Markers of cell damage – cell damage evaluation





Lipid peroxidation, a process essential for cell growth, is considered one of the main mechanisms involved in the initiation and progression of many diseases, when there is imbalance between oxidative stress-cellular antioxidant defenses. Lipid peroxidation and changes to proteins, are involved in the pathogenesis of atherosclerosis and heart disease.

The esanoil lysine is formed by the oxidation of omega 6 fatty acids, such as linoleic acid or arachidonic acid. Precisely because this is an excellent biomarker for the early stages of lipid peroxidation. Its formation can be countered by the intake of antioxidants such as flavonoids.

During the oxidation process, the amino acids constituting the proteins are modified or degraded; and formation of new functional groups such as carbonyl and hydroxyl, resulting in loss of functional activity. The proteins carbonilate are a sensitive index of damage from oxidative stress.

Other tests from RANDOX:

  • TAS (Total Antioxidant Status)
  • Ransod (Superoxide Dismutase)
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